{"id":3109,"date":"2017-04-19T14:24:06","date_gmt":"2017-04-19T12:24:06","guid":{"rendered":"https:\/\/mediagnost.de\/?page_id=3109"},"modified":"2023-08-23T12:11:41","modified_gmt":"2023-08-23T10:11:41","slug":"acid-labile-subunit-human-2","status":"publish","type":"page","link":"https:\/\/mediagnost.de\/en\/acid-labile-subunit-human-2\/","title":{"rendered":"Acid-labile Subunit human"},"content":{"rendered":"<p>The acid-labile subunit (ALS) consists of 577 amino acids and is part of the so-called ternary complex of IGF-I\/IGFBP-3 or IGFBP-5 and ALS. The formation of this complex significantly prolongs the half-life of IGF-I in circulation. It increases from <a href=\"http:\/\/joe.endocrinology-journals.org\/content\/170\/1\/63.full.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">30 -90 minutes up to 12 hours<\/a> so that the formation of the ternary complex regulates the bioavailability of IGF-I.<\/p>\n<p>So far, no diagnostic application of the ALS concentration is known. The Mediagnost test enables the reliable and reproducible measurement of ALS and thus the investigation of the biomarker properties of ALS e.g. in the field of <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dta.1562\/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+Saturday%2C+15+March+from+10%3A00-12%3A00+GMT+%2806%3A00-08%3A00+EDT%29+for+essential+maintenance&amp;userIsAuthenticated=false&amp;deniedAccessCustomisedMessage=\" target=\"_blank\" rel=\"noopener noreferrer\">Doping<\/a> or <a href=\"http:\/\/hyper.ahajournals.org\/content\/61\/6\/1281.full.pdf+html\" target=\"_blank\" rel=\"noopener noreferrer\">Preeclampsia.<\/a><\/p>\n<p>The Mediagnost ALS ELISA is suitable for the measurement of human ALS in serum and plasma. An overview of the characteristics of the test system can be found in the table below, detailed information is available in the package insert and on request.<\/p>\n<p>&nbsp;<\/p>\n<table border=\"0\" cellpadding=\"0\">\n<tbody>\n<tr bgcolor=\"#aeaeae\">\n<td colspan=\"2\" width=\"143\"><strong><span style=\"color: #ffffff;\">ALS - ELISA<\/span><br \/>\n<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"143\">Product number<\/td>\n<td width=\"174\">\n<p align=\"center\">E35<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"143\">Regulatory status<\/td>\n<td style=\"text-align: center;\" width=\"174\">\n<p align=\"center\">RUO<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"143\">Reference material<\/td>\n<td style=\"text-align: center;\" width=\"174\">recombinant ALS<\/td>\n<\/tr>\n<tr>\n<td width=\"143\">Incubation period<\/td>\n<td style=\"text-align: center;\" width=\"174\">3h<\/td>\n<\/tr>\n<tr>\n<td width=\"143\">Antibody<\/td>\n<td style=\"text-align: center;\" width=\"174\">Rabbit<\/td>\n<\/tr>\n<tr>\n<td width=\"143\">Standard<\/td>\n<td style=\"text-align: center;\" width=\"174\">native human ALS<\/td>\n<\/tr>\n<tr>\n<td width=\"143\">Assay Range [ng\/mL]<\/td>\n<td style=\"text-align: center;\" width=\"174\">0,53 - 30 000<\/td>\n<\/tr>\n<tr>\n<td width=\"143\">Samples<\/td>\n<td style=\"text-align: center;\" width=\"174\">\n<p align=\"center\">Serum<br \/>\nEDTA \/ Heparin Plasma<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"143\">Sample dilution<\/td>\n<td style=\"text-align: center;\" width=\"174\">1:150<\/td>\n<\/tr>\n<tr>\n<td width=\"143\">analyt. Sensitivity [ng\/mL]<\/td>\n<td style=\"text-align: center;\" width=\"174\">0,53<\/td>\n<\/tr>\n<tr>\n<td width=\"143\">Intra-\/Interassay Variance [%]<\/td>\n<td style=\"text-align: center;\" width=\"174\">&lt;10<\/td>\n<\/tr>\n<tr>\n<td width=\"143\">Package insert<\/td>\n<td style=\"text-align: center;\" width=\"174\"><a title=\"Package Insert E35\" href=\"https:\/\/mediagnost.de\/wp-content\/uploads\/2023\/08\/IFU-E35-RUO-ELISA-D_E-2-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/mediagnost.de\/wp-content\/uploads\/2017\/04\/pdf_icon.png\" alt=\"PDF icon\" width=\"75\" height=\"76\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>The acid-labile subunit (ALS) consists of 577 amino acids and is part of the so-called ternary complex of IGF-I\/IGFBP-3 or IGFBP-5 and ALS. The formation of this complex significantly prolongs the half-life of IGF-I in circulation. It increases from ... <a class=\"kt-excerpt-readmore\" href=\"https:\/\/mediagnost.de\/en\/acid-labile-subunit-human-2\/\" aria-label=\"Acid-labile Subunit human\">Read More<\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"_links":{"self":[{"href":"https:\/\/mediagnost.de\/en\/wp-json\/wp\/v2\/pages\/3109"}],"collection":[{"href":"https:\/\/mediagnost.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mediagnost.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mediagnost.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mediagnost.de\/en\/wp-json\/wp\/v2\/comments?post=3109"}],"version-history":[{"count":9,"href":"https:\/\/mediagnost.de\/en\/wp-json\/wp\/v2\/pages\/3109\/revisions"}],"predecessor-version":[{"id":4808,"href":"https:\/\/mediagnost.de\/en\/wp-json\/wp\/v2\/pages\/3109\/revisions\/4808"}],"wp:attachment":[{"href":"https:\/\/mediagnost.de\/en\/wp-json\/wp\/v2\/media?parent=3109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}