{"id":3105,"date":"2017-04-19T14:23:28","date_gmt":"2017-04-19T12:23:28","guid":{"rendered":"https:\/\/mediagnost.de\/?page_id=3105"},"modified":"2023-01-17T14:39:49","modified_gmt":"2023-01-17T13:39:49","slug":"igfbp-3-human-2","status":"publish","type":"page","link":"https:\/\/mediagnost.de\/en\/igfbp-3-human-2\/","title":{"rendered":"IGFBP-3 human"},"content":{"rendered":"

The IGFBP-3 assays allow sensitive determination of the concentration of IGFBP-3 in human serum and other sample matrices such as urine, follicular fluid and seminal fluid. Serum IGFBP-3 concentration is influenced by growth hormone, age, sexual development stage, diet, hypothyroidism, diabetes mellitus, liver and kidney functions. In clinical diagnostics, serum IGFBP-3 concentration can be used to diagnose growth hormone deficiency and excess.<\/p>\n

A major biological activity of IGFBP molecules is, among others, the binding and targeted release of IGF-I. Various studies have shown that increased IGFBP-3 fragmentation occurs in catabolic situations (sepsis, trauma), burns, tumor diseases, but also during pregnancy. Mediagnost therefore offers a Ligand binding assay<\/a> (E04A), which detects only IGFBP-3 that is capable of binding IGF-I.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
IGFBP-3<\/span>
\n<\/strong><\/td>\n		ELISA<\/span><\/strong><\/td>\nRIA-CT<\/span><\/strong><\/td>\nLIA<\/span><\/strong><\/td>\n<\/tr>\n
Product number<\/td>\n\n

E03A<\/p>\n<\/td>\n

\n

R11<\/p>\n<\/td>\n

\n

E04A<\/p>\n<\/td>\n<\/tr>\n

Regulatory status<\/td>\n\n

IVD<\/p>\n<\/td>\n

IVD<\/td>\nRUO<\/td>\n<\/tr>\n
Reference material<\/td>\n—<\/td>\n—<\/td>\n—<\/td>\n<\/tr>\n
Incubation period<\/td>\n2,5h<\/td>\n15h<\/td>\n3,5h<\/td>\n<\/tr>\n
Antibody<\/td>\nRabbit<\/td>\nRabbit<\/td>\nRabbit<\/td>\n<\/tr>\n
Calibrator<\/td>\nnative IGFBP-3<\/td>\nnative IGFBP-3<\/td>\nnative IGFBP-3<\/td>\n<\/tr>\n
Assay Range
\n[\u00b5g\/L]<\/td>\n		0,03 – 15150<\/td>\n0,8 – 24000<\/td>\n0,18 – 15150<\/td>\n<\/tr>\n
Samples<\/td>\n\n

Serum
\nEDTA \/ Heparin Plasma<\/p>\n<\/td>\n

Serum
\nEDTA \/ Heparin Plasma<\/td>\n		Serum
\nEDTA \/ Heparin Plasma<\/td>\n<\/tr>\n
Sample dilution<\/td>\n1:505<\/td>\n1:301<\/td>\n1:505<\/td>\n<\/tr>\n
analyt. Sensitivity
\n[\u00b5g\/L]<\/td>\n		0,03<\/td>\n0,8<\/td>\n0,18<\/td>\n<\/tr>\n
Intra-\/Interassay Variance [%]<\/td>\n<10<\/td>\n<10<\/td>\n<10<\/td>\n<\/tr>\n
Package insert<\/td>\n\"PDF<\/a><\/td>\n\"PDF<\/a><\/td>\n\"PDF<\/a><\/td>\n<\/tr>\n
Reference values<\/td>\nBlum WF, Ranke MB (1990) Use of insulin-like growth factor binding protein 3 for the evaluation of growth disorders. Horm Res 34 (Suppl):31-37<\/td>\n<\/tr>\n<\/tbody>\n<\/table>","protected":false},"excerpt":{"rendered":"

The IGFBP-3 assays allow sensitive determination of the concentration of IGFBP-3 in human serum and other sample matrices such as urine, follicular fluid and seminal fluid. Serum IGFBP-3 concentration is influenced by growth hormone, age, sexual development stage, nutrition, hypothyroidism, diabetes mellitus, liver and kidney functions ... Read More<\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"_links":{"self":[{"href":"https:\/\/mediagnost.de\/en\/wp-json\/wp\/v2\/pages\/3105"}],"collection":[{"href":"https:\/\/mediagnost.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mediagnost.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mediagnost.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mediagnost.de\/en\/wp-json\/wp\/v2\/comments?post=3105"}],"version-history":[{"count":16,"href":"https:\/\/mediagnost.de\/en\/wp-json\/wp\/v2\/pages\/3105\/revisions"}],"predecessor-version":[{"id":4458,"href":"https:\/\/mediagnost.de\/en\/wp-json\/wp\/v2\/pages\/3105\/revisions\/4458"}],"wp:attachment":[{"href":"https:\/\/mediagnost.de\/en\/wp-json\/wp\/v2\/media?parent=3105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}