IGFBP-6 (insulin-like growth factor binding protein 6) consists of 216 amino acids, but different isoforms occur, of which the one consisting of 212 amino acids is the most common. Furthermore, IGFBP-6 can be glycosylated and phophorylated. Therefore, polyclonal antibodies are used here to allow measurement of total IGFBP-6. In addition to regulating IGF bioavailability, IGFBP-6 can inhibit cell proliferation, induce apoptosis, affect angiogenesis as well as cell migration in an IGF-independent manner.

The IGFBP-6 ELISA reliably determines the concentration of human IGFBP-6 in serum, plasma and cell culture supernatants.

 

IGFBP-6 ELISA
Product number

E112

Regulatory status

RUO

Reference material eukaryotic recombinant IGFBP-6
Incubation period 3h
Antibody Rabbit
Standard recombinant human IGFBP-6
Assay Range
[µg/L]
0,026 – 500
Samples

Serum
EDTA / Heparin Plasma

Sample dilution 1:51
analyt. Sensitivity
[µg/L]
0,026
Intra-/Interassay Variance [%] < 10
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