IGFBP-1 (insulin-like growth factor binding protein 1) is a component of the IGF system and one of seven binding proteins that bind IGF-I with high affinity. It has a molecular mass of 25.3 kDa, contains 18 cysteines, and is postranslationally modified by phosphorylation, affecting IGF-I affinity . IGFBP-1 expression appears to be inhibited by insulin, whereas cortisol and glucagon stimulate its production. Also an influence on Preeclampsia is discussed in the literature.
The IGFBP-1 ELISA (insulin-like growth factor binding protein -1) reliably determines the concentration of human IGFBP-1 in serum, plasma and amniotic fluid.
| IGFBP-1- ELISA |
|
| Product number |
E01 |
| Regulatory status |
IVD |
| Incubation period | 1,75 h |
| Antibody | Mouse |
| Calibrator | native human IGFBP-1 |
| Assay Range [µg/L] |
0 – 128 |
| Samples |
Serum |
| Sample dilution | 1:16 |
| analyt. Sensitivity [µg/L] |
< 0.1 |
| Intra-/Interassay Variance [%] | < 10 |
| Package insert |  |
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