Insulin-like growth factor (IGF-II) consists of 67 amino acids with a molecular weight of 7.5kDa and is expressed in various tissues, especially during embryonic development. IGF-II binds with high affinity to a receptor without signal transduction (mannose-6-phosphate receptor) but also to IGF-I and insulin receptor. It regulates fetal growth, is often expressed by tumor cells and may have an impact in cardiovascular diseases. Mediagnost offers a test system for the measurement of IGF-II.
| IGF-II- |
ELISA |
|
| Product number |
E30 |
|
| Regulatory status |
IVD |
|
| Reference material | NIBSC 96/538 | |
| Incubation period | 3 h | |
| Antibody | Mouse / Goats | |
| Calibrator | recombinant IGF-II | |
| Assay Range [µg/L] |
0,06 – 3636 | |
| Samples |
Serum |
|
| Sample dilution | 1:404 | |
| analyt. Sensitivity [µg/L] |
0,06 | |
| Intra-/Interassay Variance [%] | <10 | |
| Package insert |  |
|
| Reference values | Blum W, Schweizer R: Insulin-like growth factors and their binding proteins; in Ranke MB (ed): Diagnostics of endocrine function in children and adolescents. Basel, Karger, 2003. Measurement was performed after acid-ethanol extraction and values were corected for recovery (factor 1.2). | |
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