Leptin is a hormone predominately synthesized by adipocytes. It consists of 167 amino acids and shows a molecular weight of 18,64kDa. Leptin is involved in the regulation of food intake and the Leptin concentration in human serum is mainly determined by body fat mass.
Mediagnost offers three different Leptin test systems, all are calibrated against the international standard NIBSC 97/594. Further, we offer bioLEP, a test system to measure biologically active Leptin. Here Leptin is measured by a combination of the leptin binding protein (extracellular part of the receptor) and a specific polyclonal antibody. This combination allows to measure only functional Leptin, which is able to bind to its receptor. An overview of major assay characteristics is given in the table below.