IGFBP-6 (insulin-like growth factor binding protein 6) consists of 216 amino acids, but different isoforms occur, of which the one consisting of 212 amino acids is the most common. Furthermore, IGFBP-6 can be glycosylated and phophorylated. Therefore, polyclonal antibodies are used here to allow measurement of total IGFBP-6. In addition to regulating IGF bioavailability, IGFBP-6 can inhibit cell proliferation, induce apoptosis, affect angiogenesis as well as cell migration in an IGF-independent manner.
The IGFBP-6 ELISA reliably determines the concentration of human IGFBP-6 in serum, plasma and cell culture supernatants.
| IGFBP-6 ELISA | |
| Product number |
E112 |
| Regulatory status |
RUO |
| Reference material | eukaryotic recombinant IGFBP-6 |
| Incubation period | 3h |
| Antibody | Rabbit |
| Standard | recombinant human IGFBP-6 |
| Assay Range [µg/L] |
0,026 – 500 |
| Samples |
Serum |
| Sample dilution | 1:51 |
| analyt. Sensitivity [µg/L] |
0,026 |
| Intra-/Interassay Variance [%] | < 10 |
| Package insert |  |
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